Assessing drug-likeness--what are we missing?

  title={Assessing drug-likeness--what are we missing?},
  author={Giulio Vistoli and Alessandro Pedretti and Bernard Testa},
  journal={Drug discovery today},
  volume={13 7-8},
The concept of drug-likeness helps to optimise pharmacokinetic and pharmaceutical properties, for example, solubility, chemical stability, bioavailability and distribution profile. A number of molecular descriptors have emerged as reasonably informative and predictive, for example, the Rule-of-Five. Here, we review some current approaches, then discuss their major shortcoming, namely the static nature of the structural features and physicochemical properties they encode. As we demonstrate… CONTINUE READING

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