Assessing changes in ages at onset over successive generation: an application to breast cancer.

@article{Hsu2000AssessingCI,
  title={Assessing changes in ages at onset over successive generation: an application to breast cancer.},
  author={Li Hsu and Lue Ping Zhao and Kathleen E. Malone and Janet R. Daling},
  journal={Genetic epidemiology},
  year={2000},
  volume={18 1},
  pages={17-32}
}
Decreased age at onset in successive generations has been observed for a number of diseases. Two nonparametric matched and unmatched test statistics are proposed, taking into account not only current age or age at death for unaffected individuals and age at disease onset for affected individuals, but also possible correlations among family members. Both are asymptotically normal with readily estimated variances from the data. A simulation study is conducted to compare the proposed tests with… CONTINUE READING

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