Assessing and improving the accuracy of detecting protein adaptation with the TreeSAAP analytical software

@article{McClellan2010AssessingAI,
  title={Assessing and improving the accuracy of detecting protein adaptation with the TreeSAAP analytical software},
  author={David A. McClellan and David D. Ellison},
  journal={International journal of bioinformatics research and applications},
  year={2010},
  volume={6 2},
  pages={
          120-33
        }
}
TreeSAAP has been used in a variety of protein studies for detecting adaptation in terms of the physicochemical properties involved in amino acid replacement. The accuracy of TreeSAAP was here tested using simulated protein-coding DNA data. A sampling of 1402 simulated amino acid replacements resulted in a default accuracy of 81.1%, with most properties exhibiting >90% accuracy. More than half of the false-positive results were traced to just 11 of the 180 possible single-step amino acid… CONTINUE READING

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