Assessing activation states in microglia.

  title={Assessing activation states in microglia.},
  author={Carol A. Colton and Donna M Wilcock},
  journal={CNS & neurological disorders drug targets},
  volume={9 2},
Since the original identification of microglia as a principal player in the brain's innate immune response, microglial activation has been widely studied. Recent studies suggest that microglial responses are heterogeneous, requiring a more precise definition of the functional outcomes of their participation in disease. Similarly to other tissue macrophages, microglia respond to inflammatory or injurious stimuli in the CNS in a pre-programmed manner that is designed to both kill and to set the… CONTINUE READING
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