Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothe

@article{Hendry2017AssessingTL,
  title={Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothe},
  author={Shona A. Hendry and Roberto Salgado and Thomas Gevaert and Prudence Anne Russell and Tom John and Bibhusal Thapa and Michael Christie and K. K. B. T. Van de Vijver and M Valeria Estrada and Paula I Gonzalez-Ericsson and Melinda O. Sanders and Benjamin R Solomon and Cinzia Solinas and Gert G. G. M. Van den Eynden and Yves Allory and Matthias Preusser and J Weis Und J Hainfellner and Giancarlo Pruneri and Andrea Vingiani and Sandra Demaria and Fraser W. Symmans and Paolo Nuciforo and Laura Comerma and E. Aubrey Thompson and Sunil Lakhani and Seong-Rim Kim and Stuart Schnitt and Cecile G A Colpaert and Christos Sotiriou and Stefan J. Scherer and Michail G Ignatiadis and Sunil S Badve and Robert H Pierce and Giuseppe Viale and Nicolas Sirtaine and Fr{\'e}d{\'e}rique Penault-Llorca and Tomohagu Sugie and Susan Fineberg and Soonmyung Paik and A. V. Srinivasan and Andrea Richardson and Yihong Wang and Ewa Chmielik and Jane Brock and Douglas B. Johnson and Justin M Balko and Stephan Wienert and Veerle Ilse Julie Bossuyt and Stefan Michiels and Nils Tern{\`e}s and Nicole Burchardi and Stephen J. Luen and Peter Savas and Frederick Klauschen and Peter Hamilton Watson and Brad H. Nelson and Carmen Criscitiello and Sandra O'toole and Denis P Larsimont and Roland de Wind and Giuseppe Curigliano and Fabrice Andre and Magali Lacroix-Triki and Mark van de Vijver and Federico Cuesta Rojo and Giuseppe Floris and Shahinaz Bedri and Joseph Sparano and David C. Rimm and Torsten Toftgard Nielsen and Zuzana Ko{\vs} and Stephen Hewitt and Baljit Singh and Gelareh Farshid and Sibylle Loibl and Kimberly H. Allison and Nadine Tung and Sylvia Adams and Karen Willard-Gallo and Hugo M. Horlings and Leena Gandhi and Andr{\'e} Moreira and Fred R Hirsch and Maria Vittoria Dieci and Mar{\'i}a Urbanowicz and Iva Br{\vc}i{\'c} and Konstanty Korski and Fabien Gaire and Hartmut Koeppen and Amy Lo and Jennifer M Giltnane and Marlon Rebelatto and Keith E. Steele and Jiping Zha and Kenneth Emancipator and Jonathan W Juco and Carsten Denkert and Jorge S Reis-Filho and Sherene Loi and Stephen B. Fox},
  journal={Advances in anatomic pathology},
  year={2017},
  volume={24 6},
  pages={
          311-335
        }
}
Assessment of the immune response to tumors is growing in importance as the prognostic implications of this response are increasingly recognized, and as immunotherapies are evaluated and implemented in different tumor types. However, many different approaches can be used to assess and describe the immune response, which limits efforts at implementation as a routine clinical biomarker. In part 1 of this review, we have proposed a standardized methodology to assess tumor-infiltrating lymphocytes… CONTINUE READING
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