Assessing Susceptibility from Early-Life Exposure to Carcinogens

  title={Assessing Susceptibility from Early-Life Exposure to Carcinogens},
  author={Hugh A. Barton and V. James Cogliano and Lynn Flowers and Larry Valcovic and R. Woodrow Setzer and Tracey J. Woodruff},
  booktitle={Environmental health perspectives},
Cancer risk assessment methods currently assume that children and adults are equally susceptible to exposure to chemicals. We reviewed available scientific literature to determine whether this was scientifically supported. We identified more than 50 chemicals causing cancer after perinatal exposure. Human data are extremely limited, with radiation exposures showing increased early susceptibility at some tumor sites. Twenty-seven rodent studies for 18 chemicals had sufficient data after… CONTINUE READING

From This Paper

Topics from this paper.
35 Citations
106 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 35 extracted citations


Publications referenced by this paper.
Showing 1-10 of 106 references

Influence of age on induction with urethan of hepatomas and other tumors in infant mice

  • M. Klein
  • J Natl Cancer Inst
  • 1966
Highly Influential
10 Excerpts

Influence of age on susceptibility to liver carcinogenesis and skin initiating action by urethane in Swiss mice

  • L Chieco-Bianchi, G De Benedictis, G Tridente
  • Br J Cancer 17:672−680
  • 1963
Highly Influential
17 Excerpts

Similar Papers

Loading similar papers…