Assessing Lead Time of Selected Ovarian Cancer Biomarkers: A Nested Case–Control Study

Abstract

BACKGROUND CA125, human epididymis protein 4 (HE4), mesothelin, B7-H4, decoy receptor 3 (DcR3), and spondin-2 have been identified as potential ovarian cancer biomarkers. Except for CA125, their behavior in the prediagnostic period has not been evaluated. METHODS Immunoassays were used to determine concentrations of CA125, HE4, mesothelin, B7-H4, DcR3… (More)
DOI: 10.1093/jnci/djp438

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