Assessing Causality in the Association between Child Adiposity and Physical Activity Levels: A Mendelian Randomization Analysis

@inproceedings{Richmond2014AssessingCI,
  title={Assessing Causality in the Association between Child Adiposity and Physical Activity Levels: A Mendelian Randomization Analysis},
  author={Rebecca C Richmond and George Davey Smith and Andrew Robert Ness and Marcel den Hoed and George Mcmahon and Nicholas J. Timpson},
  booktitle={PLoS medicine},
  year={2014}
}
BACKGROUND Cross-sectional studies have shown that objectively measured physical activity is associated with childhood adiposity, and a strong inverse dose-response association with body mass index (BMI) has been found. However, few studies have explored the extent to which this association reflects reverse causation. We aimed to determine whether childhood adiposity causally influences levels of physical activity using genetic variants reliably associated with adiposity to estimate causal… CONTINUE READING
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