Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors.

@article{PrezOtao2001AssemblyWT,
  title={Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors.},
  author={Isabel P{\'e}rez-Ota{\~n}o and Christine T. Schulteis and Anis Contractor and Stuart Lipton and James S Trimmer and Nikolaus J. Sucher and Stephen F. Heinemann},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 4},
  pages={1228-37}
}
Functional NMDA receptors are heteromultimeric complexes of the NR1 subunit in combination with at least one of the four NR2 subunits (A-D). Coexpression of NR3A, an additional subunit of the NMDA receptor family, modifies NMDA-mediated responses. It is unclear whether NR3A interacts directly with NR1 and/or NR2 subunits and how such association might regulate the intracellular trafficking and membrane expression of NR3A. Here we show that NR3A coassembles with NR1-1a and NR2A to form a… CONTINUE READING
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