Assembly rules for protein networks derived from phylogenetic-statistical analysis of whole genomes

@article{Pagel2007AssemblyRF,
  title={Assembly rules for protein networks derived from phylogenetic-statistical analysis of whole genomes},
  author={Mark Pagel and Andrew Meade and Daniel Scott},
  journal={BMC Evolutionary Biology},
  year={2007},
  volume={7},
  pages={S16 - S16}
}
We report an analysis of a protein network of functionally linked proteins, identified from a phylogenetic statistical analysis of complete eukaryotic genomes. Phylogenetic methods identify pairs of proteins that co-evolve on a phylogenetic tree, and have been shown to have a high probability of correctly identifying known functional links. The eukaryotic correlated evolution network we derive displays the familiar power law scaling of connectivity. We introduce the use of explicit phylogenetic… CONTINUE READING

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The Maximum Likelihood Approach to Reconstructing Ancestral Character States of Discrete Characters on Phylogenies

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  • Syst Biol
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