Assembly of urothelial plaques: tetraspanin function in membrane protein trafficking.

@article{Hu2005AssemblyOU,
  title={Assembly of urothelial plaques: tetraspanin function in membrane protein trafficking.},
  author={Chih-Chi Andrew Hu and F Liang and Ge Zhou and Liyu Tu and Chih-Hang Anthony Tang and Jessica Q. Zhou and Gert Kreibich and T Sun},
  journal={Molecular biology of the cell},
  year={2005},
  volume={16 9},
  pages={
          3937-50
        }
}
The apical surface of mammalian urothelium is covered by 16-nm protein particles packed hexagonally to form 2D crystals of asymmetric unit membranes (AUM) that contribute to the remarkable permeability barrier function of the urinary bladder. We have shown previously that bovine AUMs contain four major integral membrane proteins, i.e., uroplakins Ia, Ib, II… CONTINUE READING