Assembly of thick filaments and myofibrils occurs in the absence of the myosin head.

  title={Assembly of thick filaments and myofibrils occurs in the absence of the myosin head.},
  author={Richard M Cripps and Jennifer A. Suggs and Sanford I Bernstein},
  journal={The EMBO journal},
  volume={18 7},
We investigated the importance of the myosin head in thick filament formation and myofibrillogenesis by generating transgenic Drosophila lines expressing either an embryonic or an adult isoform of the myosin rod in their indirect flight muscles. The headless myosin molecules retain the regulatory light-chain binding site, the alpha-helical rod and the C-terminal tailpiece. Both isoforms of headless myosin co-assemble with endogenous full-length myosin in wild-type muscle cells. However, rod… CONTINUE READING


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