Assembly of the tight junction: the role of diacylglycerol

  title={Assembly of the tight junction: the role of diacylglycerol},
  author={Maria Susana Balda and Lorenza Gonz{\'a}lez-Mariscal and K Matter and Marcelino Cereijido and James Melvin Anderson},
  journal={The Journal of Cell Biology},
  pages={293 - 302}
Extracellular Ca2+ triggers assembly and sealing of tight junctions (TJs) in MDCK cells. These events are modulated by G-proteins, phospholipase C, protein kinase C (PKC), and calmodulin. In the present work we observed that 1,2-dioctanoylglycerol (diC8) promotes the assembly of TJ in low extracellular Ca2+, as evidenced by translocation of the TJ-associated protein ZO-1 to the plasma membrane, formation of junctional fibrils observed in freeze-fracture replicas, decreased permeability of the… CONTINUE READING
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