Assembly of the regulatory complex of the 26S proteasome

  title={Assembly of the regulatory complex of the 26S proteasome},
  author={Carlos Gorbea and Daniel Taillandier and Martin Rechsteiner},
  journal={Molecular Biology Reports},
The 19S regulatory complex (RC) of 26S proteasomes is a 900–1000 kDa particle composed of 18 distinct subunits (S1–S15) ranging in molecular mass from 25 to 110 kDa. This particle confers ATP-dependence and polyubiquitin (polyUb) recognition to the 26S proteasome. The symmetry and homogenous structure of the proteasome contrasts sharply with the remarkable complexity of the RC. Despite the fact that the primary sequences of all the subunits are now known, insight has been gained into the… CONTINUE READING
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The 26S Proteasome

  • M Rechsteiner
  • 1998
Highly Influential
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