Assembly of the membrane domain of ATP synthase in human mitochondria.

  title={Assembly of the membrane domain of ATP synthase in human mitochondria.},
  author={Jiuya He and Holly C Ford and Joe Carroll and Corsten Douglas and Evvia Gonzales and Shujing Ding and Ian M. Fearnley and John E Walker},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={115 12},
The ATP synthase in human mitochondria is a membrane-bound assembly of 29 proteins of 18 kinds. All but two membrane components are encoded in nuclear genes, synthesized on cytoplasmic ribosomes, and imported into the matrix of the organelle, where they are assembled into the complex with ATP6 and ATP8, the products of overlapping genes in mitochondrial DNA. Disruption of individual human genes for the nuclear-encoded subunits in the membrane portion of the enzyme leads to the formation of… CONTINUE READING
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