Assembly of the functional membrane attack complex of human complement: formation of disulfide-linked C9 dimers.

Abstract

The 158,000 Mr protein, previously designated C5c, present in fully assembled complement (C) membrane attack complexes (MC5b-9) has been identified as a disulfide-bonded dimer of C9. This conclusion was based on the observations that: (i) a portion of the 125I-radiolabeled precursor C9 incorporated into MC5b-9 complexes comigrated with the 158,000 Mr… (More)

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@article{Ware1981AssemblyOT, title={Assembly of the functional membrane attack complex of human complement: formation of disulfide-linked C9 dimers.}, author={Carl F Ware and Walter Kolb}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1981}, volume={78 10}, pages={6426-30} }