Assembly of the covalent linkage between lipoic acid and its cognate enzymes.

@article{Zhao2003AssemblyOT,
  title={Assembly of the covalent linkage between lipoic acid and its cognate enzymes.},
  author={Xin Yi Zhao and J Richard Miller and Yanfang Jiang and Michael A. Marletta and John E. Cronan},
  journal={Chemistry & biology},
  year={2003},
  volume={10 12},
  pages={
          1293-302
        }
}
Lipoic acid is synthesized from octanoic acid by insertion of sulfur atoms at carbons 6 and 8 and is covalently attached to a pyruvate dehydrogenase (PDH) subunit. We show that sulfur atoms can be inserted into octanoyl moieties attached to a PDH subunit or a derived domain. Escherichia coli lipB mutants grew well when supplemented with octanoate in place of lipoate. Octanoate growth required both lipoate protein ligase (LplA) and LipA, the sulfur insertion protein, suggesting that LplA… CONTINUE READING

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