Assembly of the Mycobacterial Cell Wall.

  title={Assembly of the Mycobacterial Cell Wall.},
  author={Monika Jankute and Jonathan A. G. Cox and James T. Harrison and Gurdyal S Besra},
  journal={Annual review of microbiology},
Mycobacterium tuberculosis remains one of the most successful bacterial pathogens, claiming over 1.3 million lives worldwide in 2013. The emergence of multidrug-resistant and extensively drug-resistant isolates has prompted the need for new drugs and drug targets. M. tuberculosis possesses an unusual cell wall dominated by lipids and carbohydrates that provides a permeability barrier against hydrophilic drugs and is crucial for its survival and virulence. This large macromolecular structure… CONTINUE READING
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