Assembly of retinal rod or cone Na(+)/Ca(2+)-K(+) exchanger oligomers with cGMP-gated channel subunits as probed with heterologously expressed cDNAs.

@article{Kang2003AssemblyOR,
  title={Assembly of retinal rod or cone Na(+)/Ca(2+)-K(+) exchanger oligomers with cGMP-gated channel subunits as probed with heterologously expressed cDNAs.},
  author={Kyeongjin Kang and Paul J. Bauer and Tashi G. Kinjo and Robert T. Szerencsei and Wolfgang B{\"o}nigk and Robert J. Winkfein and Paul P M Schnetkamp},
  journal={Biochemistry},
  year={2003},
  volume={42 15},
  pages={
          4593-600
        }
}
Proper control of intracellular free Ca(2+) is thought to involve subsets of proteins that co-localize to mediate coordinated Ca(2+) entry and Ca(2+) extrusion. The outer segments of vertebrate rod and cone photoreceptors present one example: Ca(2+) influx is exclusively mediated via cGMP-gated channels (CNG), whereas the Na(+)/Ca(2+)-K(+) exchanger (NCKX) is the only Ca(2+) extrusion protein present. In situ, a rod NCKX homodimer and a CNG heterotetramer are thought to be part of a single… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS

References

Publications referenced by this paper.

Assembly of Na+/Ca2+-K+ Exchanger and cGMP-Gated

  • Y. H. Su, V. D. Vacquier
  • Proc. Natl. Acad. Sci. U.S.A
  • 2003

Similar Papers

Loading similar papers…