Assembly of prototype foamy virus strand transfer complexes on product DNA bypassing catalysis of integration.


Integrase is the key enzyme that mediates integration of retroviral DNA into cellular DNA which is essential for viral replication. Inhibitors of HIV-1 that target integrase recognize the nucleoprotein complexes formed by integrase and viral DNA substrate (intasomes) rather than the free enzyme. Atomic resolution structures of HIV-1 intasomes are therefore… (More)
DOI: 10.1002/pro.2166


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