Assembly of phage Mu transpososomes: Cooperative transitions assisted by protein and DNA scaffolds

@article{Mizuuchi1995AssemblyOP,
  title={Assembly of phage Mu transpososomes: Cooperative transitions assisted by protein and DNA scaffolds},
  author={Michiyo Mizuuchi and Tania A. Baker and Kiyoshi Mizuuchi},
  journal={Cell},
  year={1995},
  volume={83},
  pages={375-385}
}
Transposition of phage Mu takes place within higher order protein-DNA complexes called transpososomes. These complexes contain the two Mu genome ends synapsed by a tetramer of Mu transposase (MuA). Transpososome assembly is tightly controlled by multiple protein and DNA sequence cofactors. We find that assembly can occur through two distinct pathways. One previously described pathway depends on an enhancer-like sequence element, the internal activation sequence (IAS). The second pathway depends… CONTINUE READING
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