Assembly of mammalian voltage-gated potassium channels: evidence for an important role of the first transmembrane segment.

@article{Babila1994AssemblyOM,
  title={Assembly of mammalian voltage-gated potassium channels: evidence for an important role of the first transmembrane segment.},
  author={T Babila and Adriana Moscucci and Hao Wang and F E Weaver and Gideon Koren},
  journal={Neuron},
  year={1994},
  volume={12 3},
  pages={615-26}
}
Three different experimental approaches were used to establish that the first transmembrane segment (S1) is important for K+ channel assembly. First, hydrodynamic analyses of in vitro translated Kv1.1 N-terminal domain containing the S1 segment coassembles to form homotetrameric complexes, whereas deletion of the S1 segment abolishes coassembly. Second, coimmunoprecipitation experiments of cotranslated Kv1.1 and Kv1.5 truncated polypeptides show that the S1 segment is essential for… CONTINUE READING

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