Assembly of fibronectin extracellular matrix.

@article{Singh2010AssemblyOF,
  title={Assembly of fibronectin extracellular matrix.},
  author={Purva Singh and Charles E. Carraher and Jean E. Schwarzbauer},
  journal={Annual review of cell and developmental biology},
  year={2010},
  volume={26},
  pages={
          397-419
        }
}
In the process of matrix assembly, multivalent extracellular matrix (ECM) proteins are induced to self-associate and to interact with other ECM proteins to form fibrillar networks. Matrix assembly is usually initiated by ECM glycoproteins binding to cell surface receptors, such as fibronectin (FN) dimers binding to α5ß1 integrin. Receptor binding stimulates FN self-association mediated by the N-terminal assembly domain and organizes the actin cytoskeleton to promote cell contractility. FN… CONTINUE READING
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