Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro

  title={Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro},
  author={Sarah Ellys Harrison and Berna Sozen and Neophytos Christodoulou and Christos Kyprianou and Magdalena Zernicka-Goetz},
Mammalian embryogenesis requires intricate interactions between embryonic and extraembryonic tissues to orchestrate and coordinate morphogenesis with changes in developmental potential. Here, we combined mouse embryonic stem cells (ESCs) and extraembryonic trophoblast stem cells (TSCs) in a three-dimensional scaffold to generate structures whose morphogenesis is markedly similar to that of natural embryos. By using genetically modified stem cells and specific inhibitors, we show that… CONTINUE READING
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