Assembly of complex RNAs by splinted ligation.

  title={Assembly of complex RNAs by splinted ligation.},
  author={Benjamin M. Akiyama and Michael D. Stone},
  journal={Methods in enzymology},
Mechanistic studies of RNA enzymes (ribozymes) and ribonucleoprotein (RNP) complexes such as the ribosome and telomerase, often seek to characterize RNA structural features, either dynamic or static, and relate these properties to specific catalytic functions. Many experimental techniques that probe RNA structure-function relationships rely upon site… CONTINUE READING