Assembly of alcohol oxidase in peroxisomes of the yeast Hansenula polymorpha requires the cofactor flavin adenine dinucleotide.

@article{Evers1994AssemblyOA,
  title={Assembly of alcohol oxidase in peroxisomes of the yeast Hansenula polymorpha requires the cofactor flavin adenine dinucleotide.},
  author={Melchior E. Evers and Vladimir I Titorenko and Ida J van der Klei and Wim Harder and Marten van der Klei Veenhuis},
  journal={Molecular biology of the cell},
  year={1994},
  volume={5 8},
  pages={829-37}
}
The peroxisomal flavoprotein alcohol oxidase (AO) is an octamer (600 kDa) consisting of eight identical subunits, each of which contains one flavin adenine dinucleotide molecule as a cofactor. Studies on a riboflavin (Rf) auxotrophic mutant of the yeast Hansenula polymorpha revealed that limitation of the cofactor led to drastic effects on AO import and assembly as well as peroxisome proliferation. Compared to wild-type control cells Rf-limitation led to 1) reduced levels of AO protein, 2… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Hitchhiking fads en route to peroxisomes

The Journal of cell biology • 2002
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…