Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains.

@article{Lockwich2000AssemblyOT,
  title={Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains.},
  author={Timothy P Lockwich and Xuedong Liu and Brij B. Singh and Julie A. Jadlowiec and Steve T. Weiland and Indu S Ambudkar},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 16},
  pages={11934-42}
}
Trp1 has been proposed as a component of the store-operated Ca(2+) entry (SOC) channel. However, neither the molecular mechanism of SOC nor the role of Trp in this process is yet understood. We have examined possible molecular interactions involved in the regulation of SOC and Trp1 and report here for the first time that Trp1 is assembled in signaling complex associated with caveolin-scaffolding lipid raft domains. Endogenous hTrp1 and caveolin-1 were present in low density fractions of Triton… CONTINUE READING

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