Assembly of Q{beta} viral RNA polymerase with host translational elongation factors EF-Tu and -Ts.

@article{Takeshita2010AssemblyOQ,
  title={Assembly of Q\{beta\} viral RNA polymerase with host translational elongation factors EF-Tu and -Ts.},
  author={Daijiro Takeshita and Kozo Tomita},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 36},
  pages={15733-8}
}
Replication and transcription of viral RNA genomes rely on host-donated proteins. Qbeta virus infects Escherichia coli and replicates and transcribes its own genomic RNA by Qbeta replicase. Qbeta replicase requires the virus-encoded RNA-dependent RNA polymerase (beta-subunit), and the host-donated translational elongation factors EF-Tu and -Ts, as active core subunits for its RNA polymerization activity. Here, we present the crystal structure of the core Qbeta replicase, comprising the beta… CONTINUE READING

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