Assembly of Helicobacter pylori initiation complex is determined by sequence-specific and topology-sensitive DnaA-oriC interactions.

Abstract

In bacteria, chromosome replication is initiated by binding of the DnaA initiator protein to DnaA boxes located in the origin of chromosomal replication (oriC). This leads to DNA helix opening within the DNA-unwinding element. Helicobacter pylori oriC, the first bipartite origin identified in Gram-negative bacteria, contains two subregions, oriC1 and oriC2… (More)
DOI: 10.1016/j.jmb.2014.05.018

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@article{Donczew2014AssemblyOH, title={Assembly of Helicobacter pylori initiation complex is determined by sequence-specific and topology-sensitive DnaA-oriC interactions.}, author={Rafał Donczew and Thorsten Mielke and Paweł Jaworski and Jolanta Zakrzewska-Czerw{\'i}nska and Anna M Zawilak-Pawlik}, journal={Journal of molecular biology}, year={2014}, volume={426 15}, pages={2769-82} }