Assembly of GABAA receptor subunits determines sorting and localization in polarized cells

@article{PerezVelazquez1993AssemblyOG,
  title={Assembly of GABAA receptor subunits determines sorting and localization in polarized cells},
  author={Jose L. Perez-Velazquez and Kimon J. Angelides},
  journal={Nature},
  year={1993},
  volume={361},
  pages={457-460}
}
THE GABAA receptor, the principal inhibitory receptor in the CNS, is distributed on cell bodies, dendrites, and in some cells at axon hillocks and presynaptic terminals1–6. The dendritic distribution is crucial for shunting of excitatory synaptic inputs7,8. Molecular cloning has revealed that the GABAA receptor can be formed by a diverse set of subunits and by separately encoded subunit isoforms9,10, the expression of each of which differs in distinct areas of the central nervous system11–13… CONTINUE READING

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