Assembly of Excitatory Synapses in the Absence of Glutamatergic Neurotransmission

@article{Sando2017AssemblyOE,
  title={Assembly of Excitatory Synapses in the Absence of Glutamatergic Neurotransmission},
  author={Richard C Sando and Eric A Bushong and Yongchuan Zhu and Min Huang and Camille Considine and S{\'e}bastien Phan and Suyeon Ju and Marco Uytiepo and Mark H. Ellisman and Anton Maximov},
  journal={Neuron},
  year={2017},
  volume={94},
  pages={312-321.e3}
}
Synaptic excitation mediates a broad spectrum of structural changes in neural circuits across the brain. Here, we examine the morphologies, wiring, and architectures of single synapses of projection neurons in the murine hippocampus that developed in virtually complete absence of vesicular glutamate release. While these neurons had smaller dendritic trees and/or formed fewer contacts in specific hippocampal subfields, their stereotyped connectivity was largely preserved. Furthermore, loss of… CONTINUE READING
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