Assembly of CNS Myelin in the Absence of Proteolipid Protein

Abstract

Two proteolipid proteins, PLP and DM20, are the major membrane components of central nervous system (CNS) myelin. Mutations of the X-linked PLP/DM20 gene cause dysmyelination in mouse and man and result in significant mortality. Here we show that mutant mice that lack expression of a targeted PLP gene fail to exhibit the known dysmyelinated phenotype… (More)
DOI: 10.1016/S0896-6273(01)80046-5

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Cite this paper

@article{Klugmann1997AssemblyOC, title={Assembly of CNS Myelin in the Absence of Proteolipid Protein}, author={Matthias Klugmann and Markus Schwab and Anja P{\"u}hlhofer and Armin Schneider and Frank Zimmermann and Ian Griffiths and Klaus-Armin Nave}, journal={Neuron}, year={1997}, volume={18}, pages={59-70} }