Assembly of 5S Ribosomal RNA Is Required at a Specific Step of the Pre-rRNA Processing Pathway

@article{Dechampesme1999AssemblyO5,
  title={Assembly of 5S Ribosomal RNA Is Required at a Specific Step of the Pre-rRNA Processing Pathway },
  author={A M Dechampesme and O. S. Koroleva and Isabelle L{\'e}ger-Silvestre and Nicole Gas and Sylvie Camier},
  journal={The Journal of Cell Biology},
  year={1999},
  volume={145},
  pages={1369 - 1380}
}
A collection of yeast strains surviving with mutant 5S RNA has been constructed. The mutant strains presented alterations of the nucleolar structure, with less granular component, and a delocalization of the 25S rRNA throughout the nucleoplasm. The 5S RNA mutations affected helix I and resulted in decreased amounts of stable 5S RNA and of the ribosomal 60S subunits. The shortage of 60S subunits was due to a specific defect in the processing of the 27SB precursor RNA that gives rise to the… CONTINUE READING

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