Assembly mechanism of the oligomeric streptolysin O pore: the early membrane lesion is lined by a free edge of the lipid membrane and is extended gradually during oligomerization.

@article{Palmer1998AssemblyMO,
  title={Assembly mechanism of the oligomeric streptolysin O pore: the early membrane lesion is lined by a free edge of the lipid membrane and is extended gradually during oligomerization.},
  author={Michael Palmer and Richard L. Harris and Christiane Freytag and Michael Kehoe and J Tranum-Jensen and Sucharit Bhakdi},
  journal={The EMBO journal},
  year={1998},
  volume={17 6},
  pages={1598-605}
}
Streptolysin O (SLO) is a bacterial exotoxin that binds to cell membranes containing cholesterol and then oligomerizes to form large pores. Along with rings, arc-shaped oligomers form on membranes. It has been suggested that each arc represents an incompletely assembled oligomer and constitutes a functional pore, faced on the opposite side by a free edge of the lipid membrane. We sought functional evidence in support of this idea by using an oligomerization-deficient, non-lytic mutant of SLO… CONTINUE READING

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