Assembly factors for the membrane arm of human complex I.

@article{Andrews2013AssemblyFF,
  title={Assembly factors for the membrane arm of human complex I.},
  author={Byron Andrews and Joe Carroll and Shujing Ding and Ian M. Fearnley and John E Walker},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 47},
  pages={18934-9}
}
Mitochondrial respiratory complex I is a product of both the nuclear and mitochondrial genomes. The integration of seven subunits encoded in mitochondrial DNA into the inner membrane, their association with 14 nuclear-encoded membrane subunits, the construction of the extrinsic arm from 23 additional nuclear-encoded proteins, iron-sulfur clusters, and flavin mononucleotide cofactor require the participation of assembly factors. Some are intrinsic to the complex, whereas others participate… CONTINUE READING
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