Assembly and regulation of ASC specks

  title={Assembly and regulation of ASC specks},
  author={Florian Hoss and Juan F Rodriguez-Alcazar and Eicke Latz},
  journal={Cellular and Molecular Life Sciences},
The inflammasome adapter ASC links activated inflammasome sensors to the effector molecule pro-caspase-1. Recruitment of pro-caspase-1 to ASC promotes the autocatalytic activation of caspase-1, which leads to the release of pro-inflammatory cytokines, such as IL-1β. Upon triggering of inflammasome sensors, ASC assembles into large helical fibrils that interact with each other serving as a supramolecular signaling platform termed the ASC speck. Alternative splicing, post-translational… CONTINUE READING


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