Assembly and mechanosensory function of focal adhesions: experiments and models.

  title={Assembly and mechanosensory function of focal adhesions: experiments and models.},
  author={Alexander D Bershadsky and Christoph Ballestrem and Letizia Carramusa and Yuliya Zilberman and Beno{\^i}t Gilquin and Saadi Khochbin and Antonina Y Alexandrova and Alexander B. Verkhovsky and Tom Shemesh and Michael M. Kozlov},
  journal={European journal of cell biology},
  volume={85 3-4},
Initial integrin-mediated cell-matrix adhesions (focal complexes) appear underneath the lamellipodia, in the regions of the "fast" centripetal flow driven by actin polymerization. Once formed, these adhesions convert the flow behind them into a "slow", myosin II-driven mode. Some focal complexes then turn into elongated focal adhesions (FAs) associated with contractile actomyosin bundles (stress fibers). Myosin II inhibition does not suppress formation of focal complexes but blocks their… CONTINUE READING


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