Assembly and expression of an intrinsic factor IX activator complex on the surface of cultured human endothelial cells.

@article{Berrettini1992AssemblyAE,
  title={Assembly and expression of an intrinsic factor IX activator complex on the surface of cultured human endothelial cells.},
  author={Mauro Berrettini and Raymond R. Schleef and Mary Jo Heeb and Pierre Hopmeier and John H Griffin},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 28},
  pages={
          19833-9
        }
}
Endothelial cells expose specific receptors for blood clotting factors and, upon perturbation, can initiate and propagate the reactions of the extrinsic pathway of blood coagulation leading to fibrin formation on the cell surface. The existence of an intrinsic mechanism of Factor IX activation on cultured human umbilical vein cells (HUVECs) was investigated by studies of the interaction between HUVECs and two proteins of the contact activation system, the cofactor high molecular weight… CONTINUE READING

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