Assembly and disassembly of cell matrix adhesions.

@article{WehrleHaller2012AssemblyAD,
  title={Assembly and disassembly of cell matrix adhesions.},
  author={Bernhard Wehrle-Haller},
  journal={Current opinion in cell biology},
  year={2012},
  volume={24 5},
  pages={569-81}
}
The formation of tissues and organs requires cells to adhere to each other and/or to migrate and polarize in contact with components of the extracellular matrix. The connection between the cytoskeleton and the extracellular environment is provided by heterodimeric transmembrane receptors of the integrin family. In response to extracellular ligand binding, integrins undergo a conformational switch that permits the recruitment of cytoplasmic adapter proteins, eventually linking the integrin… CONTINUE READING

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