Assembly and cell cycle dynamics of the nuclear lamina.

  title={Assembly and cell cycle dynamics of the nuclear lamina.},
  author={Erich A. Nigg},
  journal={Seminars in cell biology},
  volume={3 4},
The nuclear lamina is a karyoskeletal structure composed of intermediate filament type proteins. It underlies the inner nuclear membrane and confers mechanical stability to the nuclear envelope. In addition, it interacts with chromatin and may thereby participate in determining the three-dimensional organization of the interphase nucleus. During mitosis, the nuclear lamina is transiently disassembled, most probably through hyperphosphorylation of lamin proteins by the protein kinase p34cdc2, a… CONTINUE READING
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