Assembly and budding of a hepatitis B virus is mediated by a novel type of intracellular vesicles.

@article{Mhamdi2007AssemblyAB,
  title={Assembly and budding of a hepatitis B virus is mediated by a novel type of intracellular vesicles.},
  author={Mouna Mhamdi and Anneke Funk and Heinz Hohenberg and H. Will and Hueseyin Sirma},
  journal={Hepatology},
  year={2007},
  volume={46 1},
  pages={95-106}
}
UNLABELLED Formation of enveloped viruses involves assembly and budding at cellular membranes. In this study, we elucidated the morphogenesis of hepadnaviruses on the ultrastructural and biochemical level using duck hepatitis B virus (DHBV) as a model system. Formation of virus progeny initiates at the endoplasmic reticulum (ER) and is conserved both in vitro and in vivo. The morphogenesis proceeds via membrane-surrounded vesicles containing both virions and subviral particles, indicating a… CONTINUE READING
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