Assembly and Architecture of the EBV B Cell Entry Triggering Complex

@inproceedings{Sathiyamoorthy2014AssemblyAA,
  title={Assembly and Architecture of the EBV B Cell Entry Triggering Complex},
  author={Karthik Sathiyamoorthy and Jiansen Jiang and Yao Xiong Hu and Cynthia L. Rowe and Britta S. M{\"o}hl and Xiaoxiao Chen and Wei Min Jiang and Elizabeth D Mellins and Richard Longnecker and Z. Hong Zhou and Theodore S. Jardetzky},
  booktitle={PLoS pathogens},
  year={2014}
}
Epstein-Barr Virus (EBV) is an enveloped double-stranded DNA virus of the gammaherpesvirinae sub-family that predominantly infects humans through epithelial cells and B cells. Three EBV glycoproteins, gH, gL and gp42, form a complex that targets EBV infection of B cells. Human leukocyte antigen (HLA) class II molecules expressed on B cells serve as the receptor for gp42, triggering membrane fusion and virus entry. The mechanistic role of gHgL in herpesvirus entry has been largely unresolved… CONTINUE READING

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