Assembly, structure, and antigenic properties of virus-like particles rich in HIV-1 envelope gp120.

@article{Berkower2004AssemblySA,
  title={Assembly, structure, and antigenic properties of virus-like particles rich in HIV-1 envelope gp120.},
  author={Ira Berkower and Megan Raymond and Jacqueline Muller and Angelo Spadaccini and Anne Aberdeen},
  journal={Virology},
  year={2004},
  volume={321 1},
  pages={75-86}
}
In order to improve the immunogenicity of HIV-1 envelope glycoproteins, we have fused gp120 to a carrier protein, hepatitis B surface antigen (HBsAg), which is capable of spontaneous assembly into virus-like particles. The HBsAg-gp120 hybrid proteins assembled efficiently into 20-30 nm particles. The particles resemble native HBsAg particles in size and density, consistent with a lipid composition of about 25% and a gp120 content of about 100 per particle. Particulate gp120 folds in its native… CONTINUE READING
9 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…