Assembly, molecular organization, and membrane-binding properties of development-specific septins

@inproceedings{Garca2016AssemblyMO,
  title={Assembly, molecular organization, and membrane-binding properties of development-specific septins},
  author={Galo Garc{\'i}a and Gregory C. Finnigan and Lydia R. Heasley and Sarah M. Sterling and Adeeti Aggarwal and Chad G Pearson and Eva Nogales and Michael A McMurray and J. Thorner},
  booktitle={The Journal of cell biology},
  year={2016}
}
Septin complexes display remarkable plasticity in subunit composition, yet how a new subunit assembled into higher-order structures confers different functions is not fully understood. Here, this question is addressed in budding yeast, where during meiosis Spr3 and Spr28 replace the mitotic septin subunits Cdc12 and Cdc11 (and Shs1), respectively. In vitro, the sole stable complex that contains both meiosis-specific septins is a linear Spr28-Spr3-Cdc3-Cdc10-Cdc10-Cdc3-Spr3-Spr28 hetero-octamer… CONTINUE READING
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