Assembly, Trafficking and Function of γ-Secretase
@article{Kaether2006AssemblyTA, title={Assembly, Trafficking and Function of $\gamma$-Secretase}, author={Christoph Kaether and Christian Haass and Harald Steiner}, journal={Neurodegenerative Diseases}, year={2006}, volume={3}, pages={275 - 283} }
γ-Secretase catalyzes the final cleavage of the β-amyloid precursor protein to generate amyloid-β peptide, the principal component of amyloid plaques in the brains of patients suffering from Alzheimer’s disease. Here, we review the identification of γ-secretase as a protease complex and its assembly and trafficking to its site(s) of cellular function. In reconstitution experiments, γ-secretase was found to be composed of four integral membrane proteins, presenilin (PS), nicastrin (NCT), PEN-2…
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