Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23.

@article{Pan2009AssemblingSH,
  title={Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23.},
  author={Lifeng Pan and Jing Jing Yan and Lin Wu and Mingjie Zhang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 14},
  pages={5575-80}
}
The hereditary hearing-vision loss disease Usher syndrome (USH) is caused by defects in several proteins, most of which form an integrated protein network called Usher interactome. Harmonin/Ush1C is a master scaffold in the assembly of the Usher protein complexes, because harmonin is known to bind to every protein in the Usher interactome. However, the biochemical and structural mechanism governing the Usher protein complex formation is largely unclear. Here, we report that the highly-conserved… CONTINUE READING

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