Assemblies: the good, the bad, the ugly

  title={Assemblies: the good, the bad, the ugly},
  author={Ewan Birney},
  journal={Nature Methods},
It is important to chart a path forward for the genome-sequencing community, genome analysts and the downstream biology community for handling next-generation assemblies. One clear aspect is that genome assembly is not a solved problem. New sequencing technologies may provide better cost profiles for data generation but do not change some of the extremely hard problems in generating end-to-end correct sequence. This clearly requires the development of both new experimental technologies that… CONTINUE READING
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