Assay of the enantiomers of ibutilide and artilide using solid-phase extraction, derivatization, and achiral-chiral column-switching high-performance liquid chromatography.

@article{Hsu1995AssayOT,
  title={Assay of the enantiomers of ibutilide and artilide using solid-phase extraction, derivatization, and achiral-chiral column-switching high-performance liquid chromatography.},
  author={C. L. Hsu and Rodney R. Walters},
  journal={Journal of chromatography. B, Biomedical applications},
  year={1995},
  volume={667 1},
  pages={
          115-28
        }
}
  • C. Hsu, R. R. Walters
  • Published 5 May 1995
  • Chemistry
  • Journal of chromatography. B, Biomedical applications
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TLDR
A normal-phase achiral-chiral HPLC separation of the enantiomers of lifibrol and two of its metabolites was developed and validated for quantitation in dog plasma and chiral inversion of the (S)-enantiomer but not the (R-enantiomers was observed.
N-[(omega-amino-1-hydroxyalkyl)phenyl]methanesulfonamide derivatives with class III antiarrhythmic activity.
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Compound 2E appears to be as effective and 10-30 times more potent than sotalol in this model and one of the more potent analogues on the late postinfarction ventricular arrhythmias induced by programmed electrical stimulation of the canine myocardium is also described.
Effects of artilide on spontaneous and induced ventricular arrhythmias in 24‐hour canine myocardial infarction
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The electrophysiologic and antiarrhythmic effects of artilide were evaluated in dogs 24 h after myocardial infarction and results are consistent with the concept that spontaneous and pacing induced ventricular arrhythmias result from different mechanisms.