Assay of the enantiomers of ibutilide and artilide using solid-phase extraction, derivatization, and achiral-chiral column-switching high-performance liquid chromatography.

  title={Assay of the enantiomers of ibutilide and artilide using solid-phase extraction, derivatization, and achiral-chiral column-switching high-performance liquid chromatography.},
  author={C. L. Hsu and Rodney R. Walters},
  journal={Journal of chromatography. B, Biomedical applications},
  volume={667 1},
  • C. Hsu, R. R. Walters
  • Published 5 May 1995
  • Chemistry
  • Journal of chromatography. B, Biomedical applications
Sensitive method for the determination of ibutilide in human plasma by liquid chromatography-tandem mass spectrometry.
Enantioselective high-performance liquid chromatography of therapeutically relevant aminoalcohols as their fluorescent 1-naphthyl isocyanate derivatives.
A method for determining the enantiomers of 10 therapeutically relevant aminoalcohols using HPLC and precolumn derivatization was developed and detected fluorometrically in the lower ng mL(-1) range.
Pharmacokinetics of ibutilide and its enantiomers in dogs.
Ibutilide fumarate, a new drug for the treatment of cardiac arrhythmias, contains a stereogenic center bearing a secondary alcohol group, and its enantiomers exhibited high clearance rates, large volumes of distribution, and low oral bioavailability.
Recent Trends in Chiral Separations by 2D-HPLC
2D-HPLC is an important development in chiral separations due to its excellent capability to resolve the enantiomers. This article describes the latest update in the chiral resolution of racemates
Analytical Method Development Report For The Determination Of Assay & Related Substances Of Ibutilide Fumarate In Ibutilide Fumarate Injection
The aim of the study is to develop an effective assay to quantify ibutilide fumarate and its related substances in ibutilide fumarate injection. Initially, the API manufacturer’s method was followed
Recent applications of chromatographic resolution of enantiomers in pharmaceutical analysis.
The principles and applications of chromatographic separation of enantiomers in pharmaceutical analysis have been reviewed. Several of recently reported enantioselective analysis of various racemic
Recent chromatographic and electrophoretic enantioseparations of cardiovascular drugs.
The chromatographic and electrophoretic enantiomeric separation and analysis of several clinically used cardiovascular drugs have been reviewed. Several examples of recently reported applications of


Chiral assay methods for lifibrol and metabolites in plasma and the observation of unidirectional chiral inversion following administration of the enantiomers to dogs.
A normal-phase achiral-chiral HPLC separation of the enantiomers of lifibrol and two of its metabolites was developed and validated for quantitation in dog plasma and chiral inversion of the (S)-enantiomer but not the (R-enantiomers was observed.
N-[(omega-amino-1-hydroxyalkyl)phenyl]methanesulfonamide derivatives with class III antiarrhythmic activity.
Compound 2E appears to be as effective and 10-30 times more potent than sotalol in this model and one of the more potent analogues on the late postinfarction ventricular arrhythmias induced by programmed electrical stimulation of the canine myocardium is also described.
Effects of artilide on spontaneous and induced ventricular arrhythmias in 24‐hour canine myocardial infarction
The electrophysiologic and antiarrhythmic effects of artilide were evaluated in dogs 24 h after myocardial infarction and results are consistent with the concept that spontaneous and pacing induced ventricular arrhythmias result from different mechanisms.