Assay of some endogenous and synthetic sex steroids for tumor-initiating activity in rat liver using the Solt-Farber system.

@article{Schuppler1983AssayOS,
  title={Assay of some endogenous and synthetic sex steroids for tumor-initiating activity in rat liver using the Solt-Farber system.},
  author={J{\"o}rg Schuppler and Jo Van Damme and Rolf Schulte-Hermann},
  journal={Carcinogenesis},
  year={1983},
  volume={4 2},
  pages={239-41}
}
Endogenous (estradiol-17 beta; progesterone) and synthetic (ethinyl estradiol; cyproterone acetate; norethindrone acetate; norethynodrel) sex steroids were evaluated for tumor-initiating activity in the rat liver using the Solt-Farber system. All steroids were negative. This provides further evidence that tumor formation in long-term rodent bioassays by these compounds may be due to epigenetic mechanisms. 

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