Assay of catechol-O-methyltransferase activity in human erythrocytes using norepinephrine as a natural substrate.

@article{Masuda2002AssayOC,
  title={Assay of catechol-O-methyltransferase activity in human erythrocytes using norepinephrine as a natural substrate.},
  author={Mayumi Masuda and Makoto Tsunoda and Yukie Yusa and Shizuo Yamada and Kazuhiro Imai},
  journal={Annals of clinical biochemistry},
  year={2002},
  volume={39 Pt 6},
  pages={589-94}
}
BACKGROUND Catechol-O-methyltransferase (COMT) catalyses the inactivation of catecholamines. It is widely distnbuted in most tissues in soluble (S-COMT) and membrane-bound (MB-COMT) forms. Recently, we used a new assay for COMT activity and demonstrated that COMT plays an important role in blood pressure regulation in spontaneously hypertensive rats. In order to investigate whether this is true for human hypertension, we have evaluated the erythrocyte COMT assay in humans. METHOD The assay… CONTINUE READING

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